Nutribén® Natal Pro-α Codex

Nutribén® Natal Pro-α is a baby formula, suitable for newborns and onwards, when breastfeeding is not possible or insufficient. It encourages your baby’s balanced development.

The main differentiating feature of this formula is that it contains whey protein concentrate enriched with alpha-lactalbumin, the main protein in breast milk, that:1-12

  • Allows reduction of the amount of proteins, which guarantees a proper amino acid profile that is similar to that of breast milk.
  • Decreases the risk of obesity in adult life, as it reduces the amount of proteins.
  • Improves digestibility of proteins because it has a similar composition to breast milk.
  • Reduces renal solute load by reducing the amount of proteins.
  • Reduces allergenicity of proteins, by increasing the amount of alpha-lactalbumin and decreasing beta-lactoglobulin.

The formula also contains many nutrients that are essential for your baby’s development.

a) ARA and DHA13-18

  • An appropriate 1:1 ratio.
  • It encourages proper development of the Central Nervous System.
  • Proper development of visual function.
  • They aid in your baby’s proper cognitive development.

b) 100% lactose13

  • The same carbohydrate as breast milk.
  • Encourages development of Bifidobacterium and Lactobacillus: prebiotic effect.
  • Decreases growth of E. coli.
  • Improves absorption of divalent metals such as calcium and magnesium.
  • Provides galactose, which is necessary for brain development.

c) Prebiotics (GOS)19

  • More similar to breast milk.
  • 100% GOS – oligosaccharide found in breast milk.
  • Reduce constipation due to its fibre effect – Softer stools.
  • Prebiotic effect – helps growth of bifidobacteria that are found in the colon, obtaining all their benefits.
  • Strengthen the immune system.

d) Nucleotides20-26

  • More similar to breast milk.
  • Encourage development of immune system.
  • Improve intestinal development.
  • Improve vaccine response.
  • Increase iron absorption.
  • Influence metabolism of lipoproteins and long-chain polyunsaturated fatty acids.
  • Protect the intestinal flora.

e) Choline2

  • Proper synthesis of phosphatidylcholine. The main phospholipid in the brain and kidneys.
  • Important for brain development.

f) L-carnitine2

  • Correct brain development, maturation of the central nervous system and composition of cell membranes.
  • Helps properly obtain fatty acids and energy.
  • Regulates metabolism of carbohydrates, fats and proteins.

g) Inositol13

  • Important for lung development.
  • Prevents development of retinopathy and necrotising enterocolitis.
  • Mediation of cellular responses to external stimulus.

h) Minerals

  • With calcium, phosphorous and magnesium which aid in the correct development of bones in children.27
  • With iron, which encourages normal cognitive development in children.28
  • With zinc, which contributes to the normal functioning of the immune system.29
  • With selenium, which contributes to protecting DNA, proteins and fats from oxidative damage.30
  • With iodine, which contributes to normal cognitive development and normal functioning of the thyroid.31

i) Vitamins

  • With vitamin D, necessary for the normal development of bones and teeth in children.27
  • Contains vitamin C, which contributes to the correct functioning of the immune system.32-33

– Net weight: available in 400 gr. and 800 gr.

Tabla de dosificación

This table is based on average requirements, and may only be varied if indicated by your doctor.

Levelled scoops*
Boiled water (ml.)
Feeds per day
Age: 0 to 2 weeks
Age: 2 to 8 weeks
Edad: Age: 2 to 3 months
Age: 3 to 6 months
Age: 6 months and onwards

*One levelled scoop is equal to approximately 4,5 gr.


  1. 1. Infant formulas with increased concentrations of α-lactalbumin. Eric L. Lein. Am. J. Clin Nutr 2003: 77 (suppl): 1555s-8s.
  2. 2. The complete amino acid sequence of a human α-lactalbumin. Findlay, J.B.C. and Brew, K. Eur. J. Biochem, 1972. 268:239-248.
  3. 3. The complete amino acid sequence of a bovine α-lactalbumin. Brew K., Castellino, F.I., Vanaman, D.C. and Hill, R.L. J. Biol. Chem, 1970. 245:4570-4582).
  4. 4. Handbook of milk composition. Jensen. American Press. 1995: 358-360.
  5. 5. Nutritional and physiologic significance of human milk proteins. Bo Lönnerdal. Am. J. Clin. Nutr. 2003; 77 (suppl): 1537s-43s.
  6. 6. Effect of an α−lactalbumin-enriched infant formula with lower protein on growth. J. Trabulsi, R. Capeding, J. Lebumfacil, K. Ramanujan, P. Feng, S. McSweeney, B. Harris and P. DeRusso. European Journal of clinical nutrition (2011) 65, 167-174.
  7. 7. α-lactalbumin and casein-glycomarcopeptide do not affect iron absortion from formula in healthy term infants. E. Szymlek-Gay, B. Lönnerdal, S. A. Abrams, A. S. Kvistgaard, M. Domellöf and O. Hernell. The Journal of Nutrition, 142: 1226-1231, 2012.
  8. 8. Alpha-lactalbumin- enriched low-protein infant formulas: a comparison to breast-milk feeding. Heine WE, Radke M, Wutzke KD, Peters E, Kundt G. Acta Paeditr 1996; 85: 1024-8.
  9. 9. In Vitro digestion of cows milk protein by duodenal juice from infants with various intestinal disorders. Jakobson I, Lindberg T, Benediktson B. J. Paediatr. Gastroenterol. Nutri, 1982: 1:183-191.
  10. 10. Indices of protein metabolism in term infants fed Esther human milk of formulas with reduced protein concentrations and various whey/casein ratio. Janas LM, Picciano MF, Räihä NCR; Heinonen K. J. Paediatr, 1987. 110: 838-848.
  11. 11. Infant formula composition affects energetic efficiency for growth: The BeMIM study, a randomized controlled trial. M. Fleddermann, H. Demmerlmair, V. Grote, T. Nikolic, B. Trisic, B. Koletzko. Clinical nutrition. Elsevier 2013.
  12. 12. Growth and safety in term infants fed reduced-protein formula with added bovine alpha-lactalbumin. E.L. Lien, A. M. Davis, A.R. Euler and the multicenter study group. JPGN 38:170-176, 2004.
  13. 13. ESPGHAN, Committee on Nutrition. Comentario sobre el contenido y la composición de lípidos en fórmulas para lactantes. Acta Paediatrica Scandinavica 1991; 80: 887-89.
  14. 14. Report of de Scientific Committee on food on the revision of essential requirements of infant formulae and follow-on formulae (adopted on 4 April 2003) SCF/CS/NUT/IF/65 Final, 18 may 2003.
  15. 15. Kolettzko B, Thiel I, Springer S. The fatty acid composition of human milk in Europe and Africa. J. Pediatr. 1992; 120: 62-70.
  16. 16. Chappell JE.; Clandinin MT.; Kearney-Volpe C.; Reichmann B.; Swyer PW: Fatty acid balance studies in premature infants fed human milk or formula: effect of calcium supplementation J. Pediatr 1986; 108: 439 – 47.
  17. 17. Widdowson EM. Upper Limits of intake of total fat and polyunsaturated fatty acids in infant formulas. J. Nutr 1989: 119: 1814-17.
  18. 18. Auestad N.; Montalbo MB.; Hall RT y Cols: Visual acuity, erythrocyte fatty acidcomposition and qrowth in term infants fed formulas with long chain polyunsaturated fatty acid for one year. Pediatr Res 1997; 41: 1 – 10.
  19. 19. Supplementations of milk formula with galacto-oligosaccharides improve intestinal micro-flora and fermentation in term infant. Ben Xiao-Ming, et al. Chinese Medical Journal, Vol 117 (6); 927-931. 2004.
  20. 20. Advances in nutritional modifications of infant formulas. Carver DJ. Am. J. Clin. Nutr. 2003; 77 (suppl): 1550s-4s.
  21. 21. Dietary sources of nucleotides- from breast milk to weaning. Barness LA. J. Nutr.1994: 128s-130s.
  22. 22. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr1994: 124: 144-8s.
  23. 23. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-249.
  24. 24. Alimentos funcionales. La importancia de los alimentos funcionales en las leches y papillas infantiles. Rivero Urgell M, Santamaría Orleáns A, Rodríguez Palmero, Seuma Mª. Nutrición Hospitalaria 2005; XX (2): 135-146.
  25. 25. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Childh 74 (f122-f125).
  26. 26. Effects of the addition of nucleotides to an adapted milk formula on the microbial pattern of faeces in at term new born infants. Gil A. (1986) J Clin. Nutr. Gastroent.1: 127-132.
  27. 27. Reglamento 983/2009.
  28. 28. EFSA Journal 2013; 11(7): 3335.
  29. 29. EFSA Journal 2014; 12(1): 3515.
  30. 30. EFSA Journal 2014; 12(5): 3653.
  31. 31. EFSA Journal 2014; 12(11): 3890.
  32. 32. EFSA Journal 2014; 12(1): 4298.
  33. 33. EFSA Journal 2015; 13(7): 3515.