Nutribén® SIMBIOTIC is a follow-on formula, suitable for 6 months and onwards. It meets the needs of your baby at this stage.

The main characteristic of this formula is that it contains both probiotics and prebiotics in the same product. The probiotics used are Bifidobacterium lactis and Streptococcus thermophilus; Probiotics are made of 100% GOS – oligosaccharide found in breast milk.9-11

Thanks to its Symbiotic Effect, it provides the following health benefit:1-8

  • Encourages intestinal functions.
  • Strengthens baby’s natural defences.
  • Regulates intestinal transit.
  • Facilitates digestion of nutrients such as lactose.
  • Improves absorption of elements such as calcium and magnesium.

The formula also contains many nutrients that are essential for your baby’s development.

a) Carbohydrates12 that originate from lactose and provide the following benefits:

  • Encourage development of Bifidobacterium and Lactobacillus: prebiotic effect.
  • Decrease growth of E. coli.
  • Improve absorption of divalent metals such as calcium and magnesium.
  • Provide galactose, which is necessary for brain development.
  • With fast digestion and absorption maltodextrin.

b) Nucleotides13-19

  • Encourage development of immune system.
  • Improve intestinal development.
  • Improve vaccine response.
  • Increase iron absorption.
  • Influence metabolism of lipoproteins and long-chain polyunsaturated fatty acids.
  • Protect the intestinal flora.

c) Choline2

  • Proper synthesis of phosphatidylcholine. The main phospholipid in the brain and kidneys.
  • Important for brain development.

d) L- carnitine2

  • Correct brain development, maturation of the central nervous system and composition of cell membranes.
  • Helps properly obtain fatty acids and energy.
  • Regulates metabolism of carbohydrates, fats and proteins.

f) Minerals

  • With calcium, phosphorous and magnesium which aid in the correct development of bones in children..20
  • With iron, which encourages normal cognitive development in children.21-22
  • With zinc, which contributes to the normal functioning of the immune system.23
  • With selenium, which contributes to protecting DNA, proteins and fats from oxidative damage.24
  • With iodine, which contributes to normal cognitive development and normal functioning of the thyroid.25

g) Vitamins

  • With vitamin D, necessary for the normal development of bones and teeth in children. And contribute to the correct development of the immune system.20, 26
  • Contains vitamin C, which contributes to the correct functioning of the immune system and to the absorption of non-haem iron.27
  • With vitamin A, which contributes to the correct functioning of the immune system.28
  • With Riboflavin, pantothenic acid and biotin, which contribute to the normal functioning of energy metabolism.29

Dosage table
This table is based on average requirements, and may only be varied if indicated by your doctor.

Levelled scoops*
Boiled water (ml.)
Feeds per day
Age: 6 to 12 months
Age: 12 months and onwards

*One levelled scoop is equal to approximately 4,3 gr.

This product is not intended to replace breast milk and should not be used as a substitute for it. Nutribén® SYMBIOTIC is only suitable for babies above 6 months as part of a varied diet. The decision to start using complementary food should be taken according to the advice of your competent healthcare professional.


  1. 1. Fuller R. Probiotics in human medicine. Gut 1991; 32: 439-442.
  2. 2. Salminen S, Bouley C, Boutron-Ruault MC, Cummings, Franck A, Gibson GR, isolauri E, Moreau MC, Roberfroid M, Rowland I. Functional food science and gastrointestinal physiology and function. Br. J. Nutr. 1998; 80 (suppl): s147-s71.
  3. 3. Gibson GR, Roberfroid MB. Dietary modulation of the human colonia microbiota: introducing the concept of prebiotics. J. Nutr. 1995; 125: 1401-1412.
  4. 4. Collins MD, Gibson GR, Probiotics, prebiotics and symbiotics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr 1999; 69(supl):1052s-1057s.
  5. 5. José M Saavedra, Nancy a Bauman, Irene ung, Jay a Perman, Robert H Yolken. “Feeding of Bifidobacterium bifidum and Streptococcus thermophillus to infants in hospital for prevention of diarrhoea and shedding of rotavirus”. Department of Pediatrics, John Hopkins University School of Medicine and Mount Washington Pediatric Hospital, Baltimore, Maryland, USA. The Lancet, 1994. Vol 344.
  6. 6. Yaeshima, T., Takahashi, S., Matsumoto, N., Ishibashi, N., Hayasawa, H. & Iino, H. (1997), Effect of yogurt containing Bifidobacterium longum BB536 on the intestinal enviroment, fecal characteristics and defecation frequency. Bioscience Microflora 16, 53-58.
  7. 7. Bezkorovainy A, Miller-Catchpole R, Kot E. Health benefits of bifidobacteria. Tecnología lacteal latinoamericana 1997; 10: 34-41.
  8. 8. Igarashi, M., Iiyama, Y., Kato, R., Tomita, M., Asami, N. & Ezawa, I. Effect of Bifidobacterium longum and Lactulose on the strength of bone in ovariectomized osteoporosis model rats. Bifidus (1994) 7, 139-147.
  9. 9. Supplementations of milk formula with galacto-oligosaccharides improve intestinal micro-flora and fermentation in term infant. Ben Xiao-Ming, Zhou Xiao-yu, Zhao Wei-hua, Yu Wen-liang, Pan Wei, Xhang Wei-li, Wu Sheng-mei, Christien M. Van Beusekom and Anne Schaafsma. Chinese Medical Journal, Vol 117 (6); 927-931. 2004.
  10. 10. Effects of Administration of Galactooligosaccharides on the Human Faecal Microflora, Stool Weight and – Abdominal Sensation M. ITO*, Y. DEGUCHI, A. MIYAMORI, K. MATSUMOTO, H. KIKUCHI, K. MATSUMOTO, Y. KOBAYASHI, T. YAJIMA AND T. KAN MICROBIAL ECOLOGY IN HEALTH AND DISEASE VOL. 3: 285-292 (1990).
  11. 11. Galacto-oligosaccharides Are Bifidogenic and Safe at Weaning: A Double-blind Randomized Multicenter Study _Silvia Fanaro, Berit Marten, Rossana Bagna, _Vittorio Vigi, Claudio Fabris, _Luis Pena-Quintana, Federico Arguelles, Katharina E. Scholz-Ahrens, Guther Sawatzki, Richard Zelenka, y__Jurgen Schrezenmeir, y__Michael de Vrese, and Enrico Bertino.
  12. 12. Report of de Scientific Committee on food on the revision of essential requirements of infant formulae and follow-on formulae (adopted on 4 April 2003) SCF/CS/NUT/IF/65 Final, 18 may 2003.
  13. 13. Advances in nutritional modifications of infant formulas. Carver DJ. Am. J. Clin. Nutr. 2003; 77 (suppl): 1550s-4s.
  14. 14. Dietary sources of nucleotides- from breast milk to weaning. Barness LA. J. Nutr.1994: 128s-130s.
  15. 15. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J. Nutr1994: 124: 144-8s.
  16. 16. Modulation of the immune system by human milk and infant formula containing nucleotides. Pikering LK, Granoff DM, Erickson JR, Masor ML and cols. American Academy of Pediatrics. 1998; 101: 242-249.
  17. 17. Alimentos funcionales. La importancia de los alimentos funcionales en las leches y papillas infantiles. Rivero Urgell M, Santamaría Orleáns A, Rodríguez Palmero, Seuma Mª. Nutrición Hospitalaria 2005; XX (2): 135-146.
  18. 18. Nucleotide supplementation and the growth of term small for gestational age infants. Cosgrove M. (1996) Arch Dis Childh 74 (f122-f125).
  19. 19. Effects of the addition of nucleotides to an adapted milk formula on the microbial pattern of faeces in at term new born infants. Gil A. (1986) J Clin. Nutr. Gastroent.1: 127-132
  20. 20. Reglamento 983/2009.
  21. 21. EFSA Journal 2013; 11(7): 3335.
  22. 22. EFSA Journal 2014; 12(1): 3515.
  23. 23. EFSA Journal 2014; 12(5): 3653.
  24. 24. EFSA Journal 2014; 12(11): 3890.
  25. 25. EFSA Journal 2014; 12(1): 3517.
  26. 26. EFSA Journal 2015; 13 (7): 4182.
  27. 27. EFSA Journal 2015; 13(11): 4298.
  28. 28. EFSA Journal 2013; 11(7): 3334.
  29. 29. EFSA Journal 2013; 11(7): 3410.